Table 3.

Non-compartmental pharmacokinetic analysis – contrasts of ANOVA.

	Humira® EU vs. Humira® US			ONS-3010 vs. Humira® US			ONS-3010 vs. Humira® EU
	Contrast	90% CI	p-value	Contrast	90% CI	p-value	Contrast	90% CI	p-value
AUC0–inf (ng × h/mL)	1.04	0.92–1.17	0.6365	1.06	0.94–1.20	0.4061	1.03	0.91–1.16	0.7141
AUC0–last (ng × h/mL)	1.05	0.92–1.20	0.5118	1.01	0.89–1.15	0.8705	0.96	0.85–1.09	0.6160
Cmax (ng/mL)	1.07	0.99–1.15	0.1811	1.06	0.98–1.15	0.1899	1.00	0.92–1.08	0.9746