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. 2016 Nov 26;7(4):231–239. doi: 10.4331/wjbc.v7.i4.231

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©The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.

Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/

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Non-coding RNAs regulation of macrophage polarization in radiation-induced lung fibrosis. Radiation pneumonitis develops approximately 3 mo after ionizing radiation, resulting from the accumulation of M1 macrophages. Six to twelve months after ionizing radiation (IR) the accumulation of M2 macrophages activates myofibroblast differentiation, resulting in a fibrotic microenvironment and radiation-induced lung fibrosis (RILF). Non-coding RNAs regulate the pathways involved in RILF, and are temporally regulated through RILF development and progression. ECM: Extracellular matrix. This figure was produced using Servier medical art, available from http://www.servier.com/Powerpoint-image-bank.