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Three models of structural HLA class I epitope. The HLA molecule has three components: HLA chain (pink), β2-microglobulin (blue), and the bound peptide (green). The centrally located eplet (in pink) interacts with CDR-H3. Residues within a 15-Å radius are colored yellow and include configurations (in oval circles) that make contact with other CDRs on heavy chain (H1 and H2) and light chain (L1, L2, and L3). (A–C) reflect three different epitope locations on the molecule.
