Table 2A.

Associations Between HITS Metrics and Changes in WMM Metrics in White Matter Areas With FA >0.4 (> 2 SD)

	Without covariate adjustment		Covariate adjustment for age, BMI, and time between scans
	R2	p value	Adjusted R2	Covariate-adjusted R2	p value
AWF vs. RWECP	0.2129	0.0232*	0.3937	0.4438	0.0081*
Tortuosity vs. RWECP	0.1107	0.1122	0.1578	0.2528	0.1239
De axial vs. RWECP	0.1549	0.0571	0.3412	0.3494	0.0165*
De radial vs. RWECP	0.1285	0.0854	0.4076	0.3927	0.0066*
Da vs. RWECP	0.2485	0.0132*	0.5408	0.5609	0.0007*
AWF vs. RWELinear	0.0459	0.3146	0.1443	0.2150	0.1402
Tort vs. RWELinear	0.0337	0.3902	0.0321	0.1412	0.3469
De axial vs. RWELinear	0.0703	0.2106	0.2102	0.2200	0.0744
De radial vs. RWELinear	0.0554	0.2683	0.2858	0.2679	0.0326*
Da vs. RWELinear	0.0795	0.1819	0.3142	0.3442	0.0232*
AWF vs. RWERotational	0.0145	0.5756	0.1013	0.0019	0.7116
Tortuosity vs. RWERotational	0.0255	0.4560	−0.0637	0.0562	0.6303
De axial vs. RWERotational	0.0922	0.1492	0.0565	0.0682	0.2900
De radial vs. RWERotational	0.1113	0.1112	0.1525	0.1312	0.1302
Da vs. RWERotational	0.0001	0.9635	0.1406	0.0052	0.5537
AWF vs. total impacts	0.0004	0.9298	−0.0635	0.0243	0.6295
Tortuosity vs. total impacts	0.0038	0.7749	−0.0951	0.0283	0.7357
De axial vs. total impacts	0.0159	0.5575	0.0282	0.0402	0.3566
De radial vs. total impacts	0.0071	0.6964	0.0594	0.0358	0.2838
Da vs. total impacts	0.0027	0.8086	0.0256	0.0683	0.3632
AWF vs. summed linear acceleration	0.0003	0.9395	−0.0389	0.1024	0.5491
Tortuosity vs. summed linear acceleration	0.0067	0.7039	−0.0756	0.0815	0.6699
De axial vs. summed linear acceleration	0.0315	0.4069	0.0682	0.0928	0.2653
De radial vs. summed linear acceleration	0.0175	0.5381	0.1029	0.1166	0.2008
Da vs. summed linear acceleration	0.0109	0.6278	0.0804	0.2155	0.2411
AWF vs. summed rotational acceleration	0.0017	0.8463	−0.0292	0.1137	0.5187
Tortuosity vs. summed rotational acceleration	0.0097	0.6463	−0.0693	0.0873	0.6488
De axial vs. summed rotational acceleration	0.0339	0.3891	0.0637	0.0823	0.2746
De radial vs. summed rotational acceleration	0.0152	0.5666	0.0884	0.0921	0.2261
Da vs. summed rotational acceleration	0.0173	0.5397	0.0935	0.2263	0.2169

^*p < 0.05 Bold p values.

HITS, Head Impact Telemetry System; WMM, white matter modeling; FA, fractional anisotropy; SD, standard deviation; BMI, body mass index; AWF, axonal water fraction; RWEcp, Risk Weighted Cumulative Exposure combined probability; D_e axial and radial, extra-axonal diffusivity; D_a, intra-axonal diffusivity.