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Blocking DKK1 and FRZB inhibits both chondrogenic differentiation of hMSCs and chondrocyte redifferentiation. Histological analysis of GAGs using Alcian blue and safranin O staining. Collagen type II was measured by IHC and immunofluorescence staining on mid-sagittal sections of the chondrogenically differentiating hMSCs (A) and the chondrocyte (B) micromasses. GAG, glycosaminoglycan; IHC, immunohistochemistry. Color images available online at www.liebertpub.com/scd
