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. 2016 Dec 1;13(6):523–534. doi: 10.1089/zeb.2016.1339

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© Lloyd Hamilton, et al., 2016; Published by Mary Ann Liebert, Inc.

This Open Access article is distributed under the terms of the Creative Commons License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited.

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FIG. 6. — Inhibition of CSF-1R signaling leads to reduced microglia numbers and impairs U87 cell growth. U87 cells were transplanted into the larval zebrafish tectum of mpeg1:EGFP zebrafish at 3 dpf. Transplanted larvae were treated with 1% DMSO or 1% DMSO/25 μM BLZ945 from 4 dpf for 5 days. Microglial cell counts and U87 cell counts were done at 4 dpf before the start of treatment and the end of treatment (9 dpf). (A) Comparison of microglial cell numbers in control (1% DMSO) and BLZ945-treated zebrafish. Microglia numbers are displayed as the ratio (expressed as a percentage) of the final numbers at 9 dpf divided by the starting number at 4 dpf. (B) Comparison of U87 cell numbers in control (1% DMSO) and BLZ945-treated zebrafish. U87 cell numbers are displayed as the ratio (expressed as a percentage) of the final numbers at 9 dpf divided by the starting number at 4 dpf. All error bars represent the standard error of the mean. p values are indicated on graph.