FIG. 8.

Protein degradation and Alzheimer's disease. There is an inverted correlation between protein degradation mechanisms for protein quality control (or proteostasis) and Alzheimer's disease progression. Although Aβ and Tau increase their pathology, proteasome decreases its activity, perhaps allowing formation of the plaques and NFTs that are characteristic of this neurological disorder. To see this illustration in color, the reader is referred to the web version of this article at www.liebertpub.com/ars