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. 2016 Nov 28;7:542. doi: 10.3389/fimmu.2016.00542

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Copyright © 2016 Schäfer, Grosche, Reinders, Hauck, Pouw, Kuijpers, Wouters, Ehrenstein, Enzmann, Zipfel, Skerka and Pauly.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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FHR-3 serum levels in SLE patients correlated with lupus nephritis diagnose, steroid treatment, and blood sedimentation rate. FHR-3 amounts in sera of SLE patients were determined in a FHR-3-specific immunoassay. We detected a significance difference in FHR-3 concentrations in patients (A) with acute lupus nephritis, (B) patients treated with steroids versus non-steroid treatment, and (C) patients with elevated blood sedimentation rates (BSR). However, (D) age, (E) sex, (F) medication, and (G) C-reactive protein (CRP) levels did not influence the systemic FHR-3 values in SLE patients in a biologically relevant manner. ***p < 0.001, **p < 0.001, *p < 0.1 (two-tailed, unpaired t-test).