Figure 1.
Neuronal deletion of CaV1.2 does not impair fear acquisition or consolidation to a conditioned context. Mice were fear conditioned to a context using three unsignaled footshocks per day for 2 d. A, Both CaV1.2 conditional knock-out mice (n = 17) and wild-type mice (n = 17) exhibited a significant enhancement in freezing in response to the conditioned context between days 1 and 2 of training. B, When tested for their fear of the context, CaV1.2 conditional knock-out mice exhibited high levels of freezing comparable to those of wild-type mice. Data are represented as the mean ± SEM.