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Gadolinium (Gd) retention in brains of renal failure mice: similar to that observed in normal mice, Gd retention in both Gd-DTPA-BMA (linear) and Gd-DOTA (macrocyclic) groups was largely observed in the olfactory bulb. (a) There was no difference in Gd concentration after 45 days, indicating Gd isolation in the brains of mice injected with Gd-DTPA-BMA. (b) Under renal failure conditions, Gd-DOTA clearance after 45 days was found to be significant.
