Table 5.
Comparison of brain volumes between patients with Cockayne syndrome (CS) and controls (left), and between CS subtypes (right)
| Brain volume | CS patients | Controls | p-value | CS2 + COFS | CS1 + CS3 | p-value |
|---|---|---|---|---|---|---|
| WBV (mm3) | 501324.86 ± 144376 | 1154959.7 ± 132345.36 |
p < 0.001 Percentage WBV reduction: 57.06 ± 9.54% |
353792.2 ± 144376.42 | 583287.44 ± 116385.8 |
p < 0.001 Percentage WBV reduction relative to corresponding controls: CS1 + CS3: 52.4 ± 7% CS2 + COFS: 65.2 ± 9% |
| ITV (mm3) | 45366.43 ± 19.222.98 | 144049.42 ± 15126.48 |
p = 2905e−11 Percentage PFV reduction: 68.68 ± 11.9% |
31020 ± 19223 | 53336 ± 18920 | p = 0.00876 |
| STV (mm3) | 455958.43 ± 128324.65 | 1010910.3 ± 120963.38 |
p = 1.436e−11 Percentage STV reduction: 52.2 ± 9.1% |
322772 ± 153112.86 | 529950.89 ± 102618.7 | p = 0.0002417 |
| ITV/WBV | 8.9 ± 1.9% | 12.6 ± 0.9% | p < 0.001 | 9.1 ± 2.2% | 8.7 ± 1.7% | p = 0.7 |
COFS, cerebro-oculo-facio-skeletal syndrome; ITV, infratentorial volume; STV, supratentorial volume; WBV, whole-brain volume.
Values are expressed as mean ± standard deviation. p value <0.05 was considered significant.