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. 2016 Nov 28;6:37660. doi: 10.1038/srep37660

Figure 2. Morphological rescue by treatment with CoA.

Figure 2

Morphological comparison of ST-MO- (a,d), coasy-MO-injected embryos (b,e) and morphants treated with 100 μM CoA at 48 hpf (c,f). Embryos were injected with 1.2 (a–c) or 2.5 pmol/embryo (d–f). Embryos exposed to CoA showed a significant correction of the aberrant phenotype, in particular the antero-posterior development, brain and somites formation. All images are lateral views. The graph in panel G shows the mean CoA content (pmol/embryo) as measured by a specific LC-MS/MS method on extracts from embryos injected with ST-MO or coasy-MO, eventually treated with 100 μM CoA.