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. 2016 Nov 28;6:37610. doi: 10.1038/srep37610

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Copyright © 2016, The Author(s)

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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The decamer building interface region between two subunits are shown. The significant structural difference in the interface region is observed only in the residues that form the C_P-loop. Compared with “FF” (green) C_P-loop structure, the “FF_like” (blue), “LU_like” (magenta) and “LU” (cyan) is shifted away (solid arrow) from the interface region and this facilitates the destabilization of the oligomeric interface through F43 and F45 (dotted arrow). The complementary interface region formed by the neighboring subunit is shown with light colors shade.