Table 1.
Studies comparing local recurrence in ductal carcinoma in situ cases treated by breast-conserving surgery (BCS) with and without radiotherapy (RT) treatment
| Characteristic | McCormick 201518 | Wapnir 2011111 | Bijker 2006112 | Rakovitch 2013113 | ||||
|---|---|---|---|---|---|---|---|---|
| Study type | Prospective randomized control trial |
Prospective randomized control trial |
Prospective randomized control trial |
Retrospective cohort (Ontario Cancer Registry) |
||||
| Study period | 1998–2006 |
1985–1990 |
1986–1996 |
1994–2003 |
||||
| Follow-up (median) | 11 years |
17.25 years |
10 years |
10 years |
||||
| Location | Canada, USA |
USA |
Europe |
Canada |
||||
| Total (n) | 636 |
818 |
1010 |
5752 |
||||
| BCS only (n, %) | 298, 47 |
405, 49.5 |
503, 49.8 |
3762, 65.4 |
||||
| BCS + RT (n, %) | 287, 45.1 |
413, 51.1 |
507, 50.2 |
1895, 32.9 |
||||
| RT prescribed | 50.4 Gy/25 frac/5 weeks |
50 Gy/5 weeks |
50 Gy/25 frac |
50 Gy/25 frac/5 weeks |
||||
| Boost | – |
10 Gy to surgical bed |
– |
– |
||||
| Local recurrence | BCS | BCS+RT | BCS | BCS+RT | BCS | BCS+RT | BCS | BCS+RT |
| Total (%) | 6.7 | 0.9 | 35.0 | 19.8 | 26.2 | 14.8 | 19.5 | 12.3 |
| Invasive (%) | 2.8 | 0.45 | 19.6 | 10.7 | 13.0 | 8.0 | 10.0 | 7.0 |
| In situ (%) | 3.9 | 0.45 | 15.4 | 9.0 | 14.0 | 7.0 | 10.8 | 6.1 |
| Contralateral recurrence (%) | 4.8 | 3.9 | 7.9 | 9.3 | 5.8 | 7.7 | 4.8 | 5.1 |
| Breast cancer mortality (%) | 4.9 | 1.1 | 8.2 | 8.0 | 1.6 | 1.1 | 2.5 | 3.3 |
Frac, fraction.