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. 2016 Nov 28;6:37828. doi: 10.1038/srep37828

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Copyright © 2016, The Author(s)

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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(a) A proposed model showing Rac1 and RhoA control of the cytoskeleton (F-actin), AJs (E-cad), and FN deposition in IDE cells. (b,c) Different distributions of F-actin, E-cad, and FN are present in IDE cells of gerbils and mice. X, Y, Z indicate the axes in three-dimensional space. (d,e) Schematic IDE sheets show that Rac1 and RhoA participate in tissue morphogenesis and cuspal shapes by changing the cell shapes, sizes, and FN assembly. IDE, inner dental epithelium.