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. 2016 Nov 28;6:37853. doi: 10.1038/srep37853

Figure 2. Concentration profiles for regimens D2, D5 and D8 from the dosage vectors identified by the GA with deterministic modelling.

Figure 2

(a) Treatment regimen D2 maintains an antibiotic concentration above the MIC of the resistant strain throughout the 6 day treatment. The maximum total concentration of antibiotic is 60 μg/ml. (b) D5 also maintains a concentration above the MIC for the resistant bacteria throughout the 6 day treatment reaching a maximum total concentration of 54 μg/ml on day 4. (c) The concentration of antibiotic throughout D8 increases above the MIC of the resistant bacteria initially but drops back below for the first two days. The concentration is then maintained above the resistant MIC for the remainder of the treatment, reaching a maximum concentration of 58 μg/ml on day 5.