Table 2. Comparison of dosage vectors produced by the GA with deterministic modelling.
Dosage Vector | Total Antibiotic | Success Rate (%) [95% CI, n = 5000] | Time to Eradication (days) [95% CI] | |
---|---|---|---|---|
D1 | (60, 21, 22, 15, 0,0, 0, 0, 0, 0) | 118 μg/ml | 91.2 [91.0, 92.5] | 3.93 [3.88, 3.99] |
D2 | (60, 22, 18, 17, 11,0, 0, 0, 0, 0) | 128 μg/ml | 94.3 [93.6, 94.9] | 3.98 [3.94, 4.04] |
D3 | (50, 29, 22, 21, 0,0, 0, 0, 0, 0) | 122 μg/ml | 92.3 [91.5, 93.0] | 4.12 [4.06, 4.17] |
D4 | (50, 28, 20, 20, 10,0, 0, 0, 0, 0) | 128 μg/ml | 93.2 [92.5, 93.9] | 4.17 [4.11, 4.23] |
D5 | (50, 19, 21, 23, 18,10, 0, 0, 0, 0) | 141 μg/ml | 94.4 [93.7, 95.0] | 4.56 [4.50, 4.64] |
D6 | (40, 35, 23, 21, 13,0, 0, 0, 0, 0) | 132 μg/ml | 92.5 [91.7, 93.2] | 4.46 [4.41, 4.51] |
D7 | (40, 26, 26, 23, 17,11, 0, 0, 0, 0) | 143 μg/ml | 94.0 [93.2, 94.5] | 4.77 [4.71, 4.86] |
D8 | (40, 21, 27, 18, 26,13, 11, 0, 0, 0) | 156 μg/ml | 95.0 [94.4, 95.6] | 5.33 [5.26, 5.41] |
Regimens D1, D3 and D6 represent the best dosage vectors with maximum daily doses of 60, 50 and 40 μg/ml respectively. All other runs represent the best dosage vector of increased treatment duration. For Regimens D1–D8; n = 4560, 4715, 4615, 4660, 4720, 4625, 4700 and 4750 respectively.