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. 2016 Nov 28;6:37344. doi: 10.1038/srep37344

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Copyright © 2016, The Author(s)

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(a) Cranial MRIs from MS patients including gadolinium-enhanced T1 (a) and T2 images (b) were used to select tissue sections for morphological analyses. NonMS brain showed preserved white matter integrity evidenced by intense LFB staining (b1) while a MS white matter lesion displays reduced LFB detection (b2). (C) In nonMS white matter with PGN (MAB 995) detection was apparent (c1) with similar features in MS normal appearing white matter (c2). (d) Bacterial RNA polymerase beta immunoreactivity was present in nonMS (d1) and MS normal appearing white matter (d2); in situ hybridization (ISH) detection of bacterial DNA was evident in both nonMS and MS white matter (d1 and d2, insets). (Original magnification: (a–d), 10X; e-f, 20X) (Original magnification: 20X) (e) Spinning disk confocal images of cells immunolabelled with MAB 995 to PGN (red) GFAP (green) and DAPI (Blue) (Original magnification: 40X; scale bar represents 25 µm).