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. 2016 Nov 28;6:36671. doi: 10.1038/srep36671

Figure 1. The COMBI method - Summary and illustration of the methodology.

Figure 1

Receiving genotypes and corresponding phenotypes of a GWAS as input, the COMBI method first applies a machine learning step to select a set of candidate SNPs and then calculates p-values and corresponding significance thresholds in a statistical testing step.