(A) ApoE−/− mice were fed high-fat diet (triangles, n = 6, p = 0.0014), or normal chow (inverted triangles, n = 4, p = 0.0027) for 4 weeks, after which they received a bm12 heart transplant. As a control, bm12 hearts were transplanted into C57BL/6 mice fed normal chow (n = 5 squares). (B) ApoE−/− mice were fed high-fat diet and received a syngeneic cardiac graft (diamonds, n = 3 p = 0.008 compared to mice fed a high-fat diet that received a bm12 heart). (C) C57BL/6 mice were fed high-fat diet (circles, n = 7 p = 0.006) or normal chow (n = 5 squares, shown as reference) for 4 weeks after which they received a bm12 cardiac graft. Shown is the percentage of hearts surviving in each group. Data are the combined results of multiple independent experiments. ApoE, apolipoproteinE.