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. Author manuscript; available in PMC: 2016 Nov 28.
Published in final edited form as: Am J Transplant. 2015 Jun 16;15(9):2336–2345. doi: 10.1111/ajt.13350

Figure 6. Hyperlipidemia increases the frequency of alloreactive cells.

Figure 6

(A) ApoE−/− mice and C57BL/6 mice were fed high-fat diet (HFD), or normal chow for 4 weeks. Splenocytes were then harvested and stimulated with irradiated bm12 or syngeneic splenocytes and assayed for production of IL-17, IL-2, and IFN-γ by ELISpot. (B) ApoE−/− mice were fed a high-fat diet and C57BL/6 controls were fed normal chow for 4 weeks. Splenocytes were then harvested and stimulated with irradiated BALB/c or syngeneic splenocytes and assayed for production of IL-17, IL-2, and IFN-γ by ELISpot. n ≥ 5 in all groups. Asterisk indicates p < 0.05. ApoE, apolipoproteinE; IFN-g, interferon gamma; IL, interleukin.