. Author manuscript; available in PMC: 2017 Oct 1.

Published in final edited form as: Cancer Epidemiol. 2016 Jul 21;44:1–4. doi: 10.1016/j.canep.2016.07.003

Table 1.

Associations between FTO and MC4R SNPs and colorectal cancer risk in CCFR and GECCO

SNP	Discovery phase		Replication phase
	OR (95% CI)	P value	Model 1		Model 2
	OR (95% CI)	P value	OR (95% CI)	P value	OR (95% CI)	P value
FTO
rs12149832	1.18 (1.06, 1.32)	0.004	0.99 (0.95, 1.03)	0.543	1.00 (0.95, 1.04)	0.810
rs4784336^*	1.30 (1.08, 1.57)	0.005	0.99 (0.92, 1.06)	0.801	1.00 (0.93, 1.07)	0.916
rs11075990	1.17 (1.05, 1.30)	0.006	0.99 (0.95, 1.03)	0.640	1.00 (0.96, 1.04)	0.958
rs9922619	1.17 (1.05, 1.30)	0.006	0.99 (0.95, 1.03)	0.519	0.99 (0.95, 1.04)	0.749
rs11075989	1.17 (1.04, 1.31)	0.006	0.99 (0.95, 1.03)	0.639	1.00 (0.96, 1.04)	0.958
rs9930506	1.16 (1.04, 1.30)	0.007	0.99 (0.95, 1.03)	0.552	0.99 (0.95, 1.04)	0.790
rs9936385	1.16 (1.04, 1.30)	0.007	0.99 (0.95, 1.03)	0.661	1.00 (0.96, 1.04)	0.981
rs9939609	1.16 (1.04, 1.30)	0.007	0.99 (0.95, 1.03)	0.639	1.00 (0.96, 1.04)	0.957
rs9922708	1.16 (1.04, 1.29)	0.007	0.99 (0.95, 1.03)	0.542	0.99 (0.95, 1.04)	0.767
rs9930501	1.16 (1.04, 1.29)	0.007	0.99 (0.95, 1.03)	0.553	0.99 (0.95, 1.04)	0.791
rs8050136	1.16 (1.04, 1.30)	0.007	0.99 (0.95, 1.03)	0.735	1.00 (0.96, 1.04)	0.958
rs8043757	1.16 (1.04, 1.29)	0.008	0.99 (0.95, 1.03)	0.731	1.00 (0.96, 1.04)	0.956
rs17817449	1.16 (1.04, 1.29)	0.008	0.99 (0.95, 1.03)	0.708	1.00 (0.96, 1.04)	0.981
rs9932754	1.16 (1.04, 1.29)	0.008	0.99 (0.95, 1.03)	0.552	0.99 (0.95, 1.04)	0.789
rs7193144	1.16 (1.04, 1.30)	0.008	0.99 (0.95, 1.03)	0.701	1.00 (0.96, 1.04)	0.991
rs8051591	1.16 (1.04, 1.29)	0.008	0.99 (0.95, 1.03)	0.723	1.00 (0.96, 1.04)	0.970
rs9935401	1.16 (1.04, 1.29)	0.008	0.99 (0.95, 1.03)	0.725	1.00 (0.96, 1.04)	0.969
rs1420571^*	1.26 (1.06, 1.51)	0.009	0.99 (0.92, 1.06)	0.747	0.99 (0.93, 1.06)	0.827
rs7202116	1.16 (1.04, 1.29)	0.009	0.99 (0.95, 1.03)	0.637	1.00 (0.96, 1.04)	0.955
rs3751812	1.16 (1.04, 1.29)	0.009	0.99 (0.95, 1.03)	0.733	1.00 (0.96, 1.04)	0.964
rs9923233	1.16 (1.04, 1.29)	0.010	0.99 (0.95, 1.03)	0.661	1.00 (0.96, 1.04)	0.981
rs7185735	1.15 (1.03, 1.29)	0.011	0.99 (0.95, 1.03)	0.627	1.00 (0.96, 1.04)	0.940
rs17817964	1.15 (1.03, 1.29)	0.011	0.99 (0.95, 1.03)	0.680	1.00 (0.96, 1.04)	0.977
rs4784337^*	1.26 (1.05, 1.51)	0.013	0.99 (0.93, 1.06)	0.790	1.00 (0.93, 1.07)	0.889
rs7201850	1.14 (1.03, 1.28)	0.015	0.99 (0.95, 1.03)	0.579	1.00 (0.96, 1.04)	0.833
rs4784346^*	1.16 (1.03, 1.31)	0.017	1.00 (0.95, 1.04)	0.891	1.00 (0.95, 1.04)	0.870
rs8044769	0.88 (0.79, 0.98)	0.018	1.01 (0.97, 1.05)	0.582	1.01 (0.97, 1.05)	0.782
rs7186220^*	1.19 (1.03, 1.37)	0.018	1.00 (0.94, 1.05)	0.844	0.99 (0.94, 1.05)	0.772
rs9941349	1.14 (1.02, 1.27)	0.019	0.99 (0.95, 1.03)	0.620	1.00 (0.96, 1.04)	0.856
rs9931494	1.14 (1.02, 1.27)	0.019	0.99 (0.95, 1.03)	0.635	1.00 (0.96, 1.04)	0.866
rs1107355^*	1.16 (1.02, 1.31)	0.020	1.00 (0.95, 1.05)	0.914	1.00 (0.95, 1.05)	0.900
rs7194243^*	1.15 (1.02, 1.30)	0.022	1.00 (0.95, 1.04)	0.859	1.00 (0.95, 1.04)	0.850
rs9933805^*	0.88 (0.79, 0.98)	0.024	0.99 (0.95, 1.03)	0.531	0.99 (0.95, 1.03)	0.570
rs1421085	1.13 (1.01, 1.26)	0.026	1.00 (0.96, 1.04)	0.928	1.01 (0.96, 1.05)	0.805
rs1558902	1.13 (1.01, 1.26)	0.032	1.00 (0.96, 1.04)	0.937	1.01 (0.97, 1.05)	0.795
rs2024471^*	1.12 (1.01, 1.25)	0.036	1.04 (1.00, 1.08)	0.069	1.04 (1.00, 1.09)	0.052
rs12596210^*	1.20 (1.01, 1.43)	0.038	0.99 (0.93, 1.06)	0.761	0.99 (0.93, 1.06)	0.824
rs12918363	1.12 (1.00, 1.24)	0.041	0.97 (0.93, 1.01)	0.182	0.97 (0.93, 1.01)	0.127
rs1121980	1.12 (1.00, 1.25)	0.041	1.00 (0.96, 1.04)	0.840	1.00 (0.96, 1.04)	0.947
rs11075987	1.12 (1.00, 1.24)	0.044	1.01 (0.97, 1.05)	0.787	1.00 (0.96, 1.04)	0.968
rs8046502^*	1.12 (1.00, 1.24)	0.045	1.04 (1.00, 1.08)	0.066	1.04 (1.00, 1.09)	0.048
rs16952770^*	1.20 (1.00, 1.42)	0.047	0.99 (0.93, 1.06)	0.791	0.99 (0.93, 1.06)	0.811
rs4784329^*	1.12 (1.00, 1.24)	0.049	0.96 (0.92, 1.00)	0.057	0.96 (0.92, 1.00)	0.048
MC4R
rs689353	1.18 (1.06, 1.32)	0.003	1.01 (0.97, 1.05)	0.803	1.01 (0.97, 1.05)	0.798
rs598214	1.18 (1.05, 1.31)	0.004	1.01 (0.97, 1.05)	0.792	1.01 (0.97, 1.05)	0.789
rs596340	1.18 (1.05, 1.31)	0.004	1.01 (0.97, 1.05)	0.817	1.01 (0.96, 1.05)	0.811
rs545195	1.17 (1.05, 1.31)	0.005	1.01 (0.97, 1.05)	0.802	1.01 (0.97, 1.05)	0.797
rs596365	1.17 (1.05, 1.30)	0.006	1.01 (0.97, 1.05)	0.806	1.01 (0.97, 1.05)	0.801
rs1943235	0.86 (0.77, 0.96)	0.009	1.03 (0.99, 1.07)	0.228	1.02 (0.98, 1.06)	0.307
rs579054	1.16 (1.04, 1.30)	0.010	1.01 (0.96, 1.05)	0.824	1.01 (0.96, 1.05)	0.805
rs1943227^*	0.81 (0.69, 0.96)	0.012	0.94 (0.87, 1.02)	0.148	0.95 (0.87, 1.03)	0.218
rs12962636	0.75 (0.60, 0.96)	0.020	0.98 (0.88, 1.08)	0.638	0.98 (0.88, 1.09)	0.756
rs499219^*	1.22 (1.02, 1.47)	0.026	1.02 (0.96, 1.09)	0.549	1.02 (0.96, 1.09)	0.523
rs560248^*	1.14 (1.01, 1.28)	0.032	1.02 (0.98, 1.07)	0.359	1.02 (0.98, 1.07)	0.323
rs12966035	0.89 (0.80, 0.99)	0.035	1.01 (0.97, 1.05)	0.692	1.01 (0.97, 1.05)	0.791
rs12953429	1.12 (1.01, 1.25)	0.037	0.99 (0.95, 1.03)	0.683	0.99 (0.95, 1.03)	0.523
rs489310^*	1.20 (1.01, 1.43)	0.038	1.02 (0.96, 1.09)	0.511	1.02 (0.96, 1.09)	0.499
rs547363	0.89 (0.80, 0.99)	0.040	1.00 (0.96, 1.04)	0.905	1.00 (0.96, 1.04)	0.983
rs2156335^*	0.89 (0.80, 1.00)	0.041	1.02 (0.98, 1.06)	0.412	1.01 (0.97, 1.06)	0.496
rs4378703^*	1.15 (1.00, 1.32)	0.047	1.01 (0.96, 1.07)	0.612	1.01 (0.96, 1.07)	0.729
rs612238^*	1.20 (1.00, 1.43)	0.048	1.03 (0.96, 1.09)	0.457	1.03 (0.96, 1.10)	0.440

Abbreviations:

CCFR, Colon Cancer Family Registry; CI, confidence interval; FTO, fat-mass and obesity-associated; GECCO, Genetics and Epidemiology of Colorectal Cancer Consortium; MC4R, melanocortin-4 receptor; OR, odds ratio; SNP, single nucleotide polymorphism.

Note:

Model 1: adjusted for age, sex, and the top three principal components of ancestry

Model 2: adjusted for age, sex, body mass index, and the top three principal components of ancestry Odd ratio, 95% CI and P values in the discovery phase obtained from model 1 (SNPs with no *) or model 2 (SNPs with *), whichever generates the smaller p value, from the meta-analyses.