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Combined PI3K and PARP suppression in vivo. Tumor growth of TNBC1, TNBC2, and TNBC3 xenografts treated with vehicle control, BKM120 (27.5 mg/kg), olaparib (Olap; 50 mg/kg), or the combination of both agents. Relative tumor volumes are displayed as mean ± SE of a minimum of 6 tumors per arm. *, P < 0.001 combination versus BKM120 arm.
