Figure 2. Lymphocyte proliferative responses to IVE-TB proteins in individuals with different exposures to Mtb.

(a) Donors (n = 19) were divided into three groups based on their lymphocyte proliferative response to Mtb ESAT6/CFP10 (E/C) or PPD. The total number of antigens recognised (left) and the overall magnitude of responses generated (right) after stimulation are indicated per individual as a closed circle (•). (b) Donors were ranked according to the lymphocyte proliferation responses to PHA, PPD, E/C, the total proliferation, and the number of antigens recognised. The correlation among these variables was measured by Spearman r, and the statistical significance was expressed by two-tailed p-value.