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. 2016 Mar 1;32(3):262–270. doi: 10.1089/aid.2015.0189

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Copyright 2016, Mary Ann Liebert, Inc.

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FIG. 2. — (A) A micrograph image of a typical granuloma illustrating the region of interest used for our analysis of CD68 immunolocalization (initial magnification, ×40). CD68-positive cells appear in pink and nuclei in blue. This image illustrates a typical granuloma with positively stained (pink) macrophages counted for semiquantitative analyses of intensity and area of immunolocalization. (B) A graphic illustration of the association (rho = 0.6; p > 0.05; 95% CI) between the area of CD68 immunoreactivity and the overall mean intrapatient genetic distance of plasma-derived and tissue-derived sequences. (C) A light micrograph and (D, E) transmission electron micrographs (TEM) of the spinal TB granulomas. Localization of macrophages (pink) and HIV p24 (black) appear in (C) (initial magnification ×40) with colocalized CD68⁺/p24⁺ within the same cells indicated by an arrow. (D) A TEM showing a bacterial cell (arrowhead) within an intracellular membrane-bound compartment. (E) Virus particles (arrows) were also observed, under TEM, within a similar membrane-bound intracellular compartment of a cell displaying macrophage morphology [(D, E) initial magnification ×50].