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. Author manuscript; available in PMC: 2017 Sep 14.
Published in final edited form as: Sci Transl Med. 2016 Sep 14;8(356):356ra119. doi: 10.1126/scitranslmed.aad9943

Figure 5. Transcriptome analysis of IL-6 treated CD4+CD25− T cells from patients with T1D.

Figure 5

(A) Network of enriched KEGG pathway cytokine- cytokine receptor interaction illustrates cluster of IL-6-induced genes involved in T cell trafficking. Chemokine receptors are shown in color. (B) Fold change up-regulation, expression level (logCPM) and P value of the chemokine receptors identified in (A). (C) GO analysis of IL-6-induced genes shows enrichment of terms associated with cell migration and regulation of inflammatory responses. (D) Heat map of immune-relevant genes demonstrating consistent up-regulation by IL-6 across subjects. (Left) Unstimulated cells. (Right) IL-6-stimulated cells from the same subjects. (E) Linear regression showing positive correlation between IL-6/pSTAT3 and expression level of CCR7 and SELL in CD3+ T cells; n = 6 (Ctrl) and n = 6 (T1D). r = Pearson correlation coefficient.