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. Author manuscript; available in PMC: 2016 Nov 28.
Published in final edited form as: Stem Cells. 2015 Nov 17;34(2):405–417. doi: 10.1002/stem.2235

Figure 1.

Figure 1

Hematopoietic stem cell (HSC) imbalance in diabetic ataxia telangiectasia mutated (ATM)−/−→ wild type (WT) chimeras. (A): Representative scheme for flow cytomtery dot plot used to differentiate and quantify long-term repopulating (LTR) and short-term repopulating (STR)-HSCs. Lin−Scal1+ c-kit+ CD34− and Lin−Scal1+ c-kit+ CD34+ were identified as LTR-HSCs and STR-HSCs, respectively. Bar chart showing a quantification of (B) LTR-HSCs and (C) STR-HSCs. WT (n = 12), WT+ STZ (n = 5), ATM−/−→WT (n = 5), ATM−/−→WT (n = 5). Statistical test one way analysis of variance followed by Student’s Newman Keul Test. Abbreviations: ATM, ataxia telangiectasia mutated; FSCA, forward-scattered light area; HSC, hematopoietic stem cell; LTR, long-term repopulating; SSCA, side-scattered light area; STZ, streptozotocin; WT, wild type.