Figure 7.

Effect of long‐term culture and NP‐siRNA treatment on the molecular processes and signaling pathways: Up‐regulated (A) and down‐regulated (C) genes in each comparison (x‐axis) are enriched in the pathways shown on y‐axis. Coloring yellow to red represents low to high enrichment estimated using −log₁₀ (p‐values). Adjusted p‐values are provided in the Supporting Information Table S5. Heatmap of differentially expressed genes within apoptosis (B) enriched signaling pathway, where color refers to log₂(fold‐change) in expression (blue indicates down regulation and yellow indicates upregulation). Abbreviations: D = day; NT = no treatment