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. Author manuscript; available in PMC: 2017 Nov 17.
Published in final edited form as: Cell. 2016 Nov 17;167(5):1188–1200. doi: 10.1016/j.cell.2016.10.024

Figure 1. The enhancer-gene specificity conundrum.

Figure 1

A. Model of a genomic region encompassing an enhancer and two genes. The features that cause an enhancer to regulate only specific genes are still not fully understood, which we refer to as the enhancer-gene specificity conundrum

B. Model of a genomic region encompassing an enhancer and two genes with the transcription factor CTCF bound in-between. CTCF is a component of enhancer-blocking insulators, but which CTCF-bound sites function as an insulator in vivo is still unclear.