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. Author manuscript; available in PMC: 2017 Nov 17.
Published in final edited form as: Cell. 2016 Nov 17;167(5):1188–1200. doi: 10.1016/j.cell.2016.10.024

Figure 4. Insulated neighborhoods are the mechanistic basis of TADs.

Figure 4

A. Hi-C and cohesin ChIA-PET identify similar Topologically Associating Domains (TAD). Bars indicate the TADs identified using Hi-C and ChIA-PET in human ESCs at the genomic region whose co-ordinates are indicated in the bottom.

B. Model of a TAD that consists of an insulated neighborhood

C. Model of a TAD that consists of nested insulated neighborhoods

D. Model of a TAD that consists of two insulated neighborhoods, nested within a TAD-spanning CTCF-CTCF loop