A. Hi-C and cohesin ChIA-PET identify similar Topologically Associating Domains (TAD). Bars indicate the TADs identified using Hi-C and ChIA-PET in human ESCs at the genomic region whose co-ordinates are indicated in the bottom.
B. Model of a TAD that consists of an insulated neighborhood
C. Model of a TAD that consists of nested insulated neighborhoods
D. Model of a TAD that consists of two insulated neighborhoods, nested within a TAD-spanning CTCF-CTCF loop