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. Author manuscript; available in PMC: 2016 Nov 28.
Published in final edited form as: DNA Repair (Amst). 2014 May 10;20:2–13. doi: 10.1016/j.dnarep.2014.02.003

Fig. 7.

Fig. 7

Magnetic tweezer strategies. (A) DNA (blue) is tethered between a surface and paramagnetic beads (orange) attracted toward the magnets. By rotating the magnets twist can be applied to the DNA forming plectonemes which in turn allow for very high resolution measurements of changes in the DNA structure. (B) In this strategy the magnet can be manipulated to bring DNA close to the surface and can therefore be used in conjunction with TIRF imaging. This has an advantage over laser tweezers in that all beads in the visual field will behave similarly, permitting multiplexing.