Fig. 1.

Evolvement of clustering and the development of recurrence patterns (“mini-hotspot” mutations; circles) of somatic mutations affecting the ERBB4 gene in melanoma upon combining sequencing results from candidate gene family sequencing and exomic and whole-genome sequencing studies (previously identified mutations listed as black arrows on bottom, mutations identified as part of the NIH, Clinical Genomic Core profiling (clinical trial samples), listed in red on top (unpublished))