Concentration in serum |
~0.6–3.3 mg/ml |
~2–80 μg/ml |
~4 μg |
Concentration in gut mucus |
~75 μg/ml |
Not determined |
~7 μg |
Structure |
Tetramer in serum (~700 kDa) and mucus (~800 kDa) |
Long (~370–400 kDa) and short (~240 kDa) monomer |
Monomer (~180 kDa) in serum, multimer in mucus (~4–5 monomers) |
Demonstrated effector functions |
Complement activation, opsonization, neutralization, immune exclusion |
Not determined |
Immune exclusion? |
Coating of intestinal microbiota |
Yes |
Not determined |
Yes |
Pathogen-specific responses |
Mainly detected in serum |
Not determined |
Mainly detected in mucus |