Table 2. Associations between markers of renal function and serum angiopoietin-2 concentration or serum Tie-2 concentration.
| Angiopoietin-2 | Tie-2 | Angiopoietin-2 | Tie-2 | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Beta | Stderr | P | Beta | Stderr | P | Beta | Stderr | P | Beta | Stderr | P | |
| SHIP-1 | ||||||||||||
| Creatinine | -1.88E-03 | 1.16E-03 | 0.10 | -9.80E-04 | 6.02E-03 | 0.87 | 1.09E-03 | 8.80E-04 | 0.22 | -3.80E-03 | 1.03E-02 | 0.71 |
| Creatinine' | 1.67E-06 | 5.04E-07 | <.01 | - | - | - | - | - | - | |||
| eGFR(crea) | -3.53E-03 | 9.95E-04 | <.01 | -1.15E-03 | 5.21E-03 | 0.83 | -7.05E-04 | 6.59E-04 | 0.29 | 3.05E-03 | 7.71E-03 | 0.69 |
| eGFR(crea)' | 9.76E-07 | 3.09E-07 | <.01 | - | - | - | - | - | - | - | - | - |
| Cystatin C | 0.39 | 0.04 | <.01 | 5.84 | 1.26 | <.01 | 0.35 | 0.08 | <.01 | 3.67 | 0.97 | <.01 |
| Cystatin C' | - | - | - | -15.03 | 4.87 | <.01 | - | - | - | - | - | - |
| eGFR(cys) | -5.53E-03 | 8.00E-04 | <.01 | -9.24E-03 | 9.54E-03 | 0.33 | -3.73E-03 | 8.44E-04 | <.01 | -3.78E-02 | 9.88E-03 | <.01 |
| eGFR(cys)' | 3.58E-07 | 1.74E-07 | 0.04 | -5.08E-06 | 2.07E-06 | 0.01 | - | - | - | |||
| log(uACR) | 3.67E-02 | 7.10E-03 | <.01 | 0.20 | 0.08 | 0.02 | 3.51E-02 | 1.23E-02 | <.01 | 0.28 | 0.15 | 0.05 |
| SHIP-Trend | ||||||||||||
| Creatinine | -2.39E-03 | 9.76E-04 | 0.01 | 9.99E-03 | 4.80E-03 | 0.04 | -2.97E-03 | 1.54E-03 | 0.05 | 1.31E-02 | 7.47E-03 | 0.08 |
| Creatinine' | 1.64E-06 | 4.41E-07 | <.01 | - | - | - | 2.37E-06 | 9.18E-07 | 0.01 | - | - | - |
| eGFR(crea) | -3.48E-03 | 8.03E-04 | <.01 | -7.69E-03 | 3.78E-03 | 0.04 | -2.42E-03 | 1.22E-03 | 0.05 | -7.02E-03 | 5.16E-03 | 0.17 |
| eGFR(crea)' | 1.12E-06 | 2.40E-07 | <.01 | - | - | - | 9.51E-07 | 4.22E-07 | 0.02 | - | - | - |
| Cystatin C | 0.25 | 0.12 | 0.03 | 1.18 | 0.54 | 0.03 | 0.05 | 0.20 | 0.81 | 2.53 | 0.90 | <.01 |
| Cystatin C' | 1.67 | 0.86 | 0.05 | - | - | - | 5.81 | 2.27 | 0.01 | - | - | - |
| eGFR(cys) | -4.79E-03 | 4.99E-04 | <.01 | -1.20E-02 | 5.53E-03 | 0.03 | -7.76E-03 | 1.29E-03 | <.01 | -2.50E-02 | 9.19E-03 | 0.01 |
| eGFR(cys)' | - | - | - | - | - | - | 1.45E-06 | 5.98E-07 | 0.02 | - | - | - |
| log(uACR) | 5.47E-02 | 7.10E-03 | <.01 | -0.60 | 0.22 | <.01 | 6.46E-02 | 1.26E-02 | <.01 | -1.01 | 0.39 | <.01 |
| log(uACR)' | - | - | - | 9.52E-02 | 3.62E-02 | <.01 | - | - | - | 0.23 | 0.09 | 0.01 |
eGFR = estimated glomerular filtration rate based on either serum creatinine [eGFR(crea)] or serum cystatin C concentration [eGFR(cys)]. All models were adjusted for age, sex, waist circumference, smoking, total cholesterol, systolic and diastolic blood pressure and additionally in the whole population for diabetes mellitus type 2 and use of antihypertensive or antidiabetic medication. Creatinine', eGFR' and cystatin C' represent spline components, for more detail see method section.