Table 1. Genes exhibiting significant (FDR-adjusted P-value < 0.005, average contrast log2(fold change) > |2|) activity genotype-by-environment interaction.
| Gene | Contrast Log2(Fold Change)c | FDR | ||||||
|---|---|---|---|---|---|---|---|---|
| Namea | UCSC IDb | CB-HB | CB-CF | CB -HF | HB-CF | HB-HF | CF-HF | P-value |
| Adora2a | uc007fqh.1 | -4.02 | -4.87 | -4.72 | -0.85 | -0.70 | 0.15 | 2.57E-14 |
| Arhgap8 | uc007xch.2/uc007xck.2 | 2.07 | -3.51 | 2.26 | -5.58 | 0.19 | 5.76 | 2.31E-11 |
| Cpne4 | uc009rhr.1 | -3.46 | -4.77 | -3.56 | -1.31 | -0.10 | 1.21 | 2.57E-14 |
| Cpne5 | uc008bsj.2/uc008bsk.2 | -4.54 | -5.76 | -4.82 | -1.22 | -0.28 | 0.94 | 2.57E-14 |
| Ctxn1 | uc009ktp.2 | -3.85 | -4.60 | -4.05 | -0.75 | -0.21 | 0.54 | 2.57E-14 |
| Ddn | uc007xny.1 | -5.12 | -7.65 | -6.92 | -2.53 | -1.80 | 0.73 | 2.57E-14 |
| Drd2 | uc009pja.1 | -4.18 | -4.84 | -4.10 | -0.66 | 0.08 | 0.74 | 2.57E-14 |
| Egr3 | uc007unb.1 | -4.49 | -5.93 | -5.50 | -1.44 | -1.01 | 0.43 | 2.57E-14 |
| Gda | uc008gyx.1 | -4.61 | -6.54 | -5.30 | -1.94 | -0.69 | 1.25 | 2.57E-14 |
| Gpr88 | uc008rbz.2 | -4.48 | -6.43 | -5.94 | -1.94 | -1.45 | 0.49 | 2.57E-14 |
| Icam5 | uc009oka.2 | -4.58 | -6.22 | -5.70 | -1.64 | -1.12 | 0.52 | 2.57E-14 |
| Kcnj4 | uc007wtn.2 | -4.60 | -6.17 | -5.48 | -1.58 | -0.88 | 0.69 | 2.57E-14 |
| Lamp5 | uc008mog.1 | -2.96 | -4.53 | -3.88 | -1.57 | -0.92 | 0.66 | 2.57E-14 |
| Lrrc10b | uc012bio.2 | -4.44 | -5.64 | -5.26 | -1.20 | -0.82 | 0.38 | 2.57E-14 |
| Nrgn | uc009ovc.1 | -4.50 | -5.51 | -4.03 | -1.01 | 0.48 | 1.48 | 2.57E-14 |
| Nts | uc007gye.1 | -3.36 | -4.73 | -3.36 | -1.37 | 0.00 | 1.37 | 5.21E-08 |
| Rxrg | uc007dla.2/uc007dlb.2 | -3.84 | -5.29 | -4.37 | -1.45 | -0.52 | 0.92 | 2.57E-14 |
| Scd4 | uc008hpq.1 | 3.28 | -1.66 | 3.17 | -4.95 | -0.11 | 4.84 | 2.57E-14 |
| Sst | uc007ytx.1 | -4.16 | -4.61 | -3.54 | -0.45 | 0.62 | 1.07 | 2.57E-14 |
| Tbr1 | uc008jvd.1 | -3.99 | -4.94 | -4.66 | -0.95 | -0.67 | 0.28 | 2.57E-14 |
a Adora2a = adenosine A2a receptor; Arhgap8 = Rho GTPase activating protein 8; Cpne4 = copine IV; Cpne5 = copine V; Cyp11a1 = cytochrome P450, family 11, subfamily a, polypeptide 1; Ddn = dendrin; Drd2 = dopamine receptor D2; Gda = guanine deaminase; Gpr88 = G-protein coupled receptor 88; Icam5 = intercellular adhesion molecule 5, telencephalin; Kcnj4 = potassium inwardly-rectifying channel, subfamily J, member 4; Lamp5 = lysosomal-associated membrane protein family, member 5; Lrrc10b = leucine rich repeat containing 10B; Nrgn = neurogranin; Nts = neurotensin; Rxrg = retinoid X receptor gamma; Scd4 = stearoyl-coenzyme A desaturase 4; Sst = somatostatin; Tbr1 = T-box brain gene 1;
b University of California Santa Cruz genome browser identifier.
c Log2Fold is the log2-transformed fold change between 2 genotype-environment groups. When considering groups A vs B = A—B, Log2Fold Change = Log2 (A/B). Groups are: CB = low activity genotype-low activity environment; CF = low activity genotype-high activity environment; HB = High activity genotype-low activity environment; HF = High activity genotype-high activity environment