Table 3. Minor allele frequency for each SNP, selected from four candidate genes in the 5-LOX pathway.
| SNP | Genomic position | Allele | Sub cohort | Cases | ||
|---|---|---|---|---|---|---|
| ALOX-5 | ||||||
| rs12762303 | 10: 45373723 | C/T | 14.9 | (833) | 14.4 | (809) |
| rs59439148 | 10: 4537413(2–7) | V/W | 15.8 | (891) | 15.3 | (863) |
| FLAP | ||||||
| rs17222814 | 13: 30725416 | A/G | 11.0 | (619) | 10.6 | (599) |
| rs4073259 | 13: 30732134 | G/A | 35.9 | (2,004) | 35.3 | (1,983) |
| rs10507391 | 13: 30737959 | A/T | 32.9 | (1,855) | 32.4 | (1,836) |
| rs4769874 | 13: 30752304 | A/G | 3.8 | (213) | 3.6 | (200) |
| rs9551963 | 13: 30758410 | A/C | 50.3 | (2,831) | 48.2 | (2,723) |
| rs9315050 | 13: 30761908 | G/A | 6.1 | (342) | 6.5 | (366) |
| rs17222842 | 13: 30765980 | A/G | 10.7 | (598) | 9.7 | (547) |
| LTC4-S | ||||||
| rs730012 | 5: 179793637 | C/A | 30.4 | (1,705) | 31.3 | (1,765) |
| LTA4-H | ||||||
| rs61937881 | 12: 95999809 | T/C | 24.3 | (1,349) | 25.7 | (1,440) |
| rs2660880 | 12: 96007474 | A/G | 6.8 | (385) | 6.8 | (387) |
| rs6538697 | 12: 96009832 | C/T | 7.2 | (408) | 7.4 | (419) |
| rs1978331 | 12: 96015423 | C/T | 38.3 | (2,144) | 39.9 | (2,249) |
| rs17677715 | 12: 96020673 | C/T | 17.7 | (998) | 19.0 | (1,076) |
| rs2247570 | 12: 96028599 | G/A | 29.5 | (1,653) | 30.8 | (1,735) |
| rs2660898 | 12: 96032219 | G/T | 31.8 | (1,783) | 33.1 | (1,872) |
| rs2540482 | 12: 96041102 | G/A | 22.5 | (1,263) | 22.1 | (1,251) |
| rs2540477 | 12: 96043776 | C/T | 22.0 | (1,238) | 21.7 | (1,228) |
| rs2660845 | 12: 96044775 | G/A | 26.0 | (1,460) | 25.6 | (1,447) |
| rs2540475 | 12: 96047515 | T/C | 20.5 | (1,159) | 20.0 | (1,131) |
Abbreviations: SNP, Single nucleotide polymorphism; ALOX-5, Arachidonate 5-lipoxygenase; FLAP, 5-lipoxygenase activating protein; LTC4-S, Leukotriene C4 synthase; LTA4-H, Leukotriene A4 hydroxylase.
Results presented as allele frequencies (n) for the minor allele(underlined). The two SNPs (rs17216473 & rs3776944) did not display variation in our study population. Alleles correspond to the positive DNA-strand and genomic position are obtained from dbSNP, human assembly GRCh38.p2.