Table 5. Association of selected haplotypes in FLAP and LTA4-H with incident myocardial infarction.
| Haplotype | Freq. (%) | Model A1* | pa | Model A2** | pa | ||
|---|---|---|---|---|---|---|---|
| FLAP | |||||||
| Hap-A (GGAT) | 14.0 | 0.97 | (0.87;1.08) | 0.58 | 0.92 | (0.82;1.04) | 0.18 |
| Hap-B (AAG) | 19.8 | 1.02 | (0.93;1.12) | 0.71 | 1.02 | (0.92;1.13) | 0.71 |
| LTA4-H | |||||||
| Hap-K (CGTTTATGGC) | 14.5 | 0.94 | (0.85;1.05) | 0.28 | 0.91 | (0.82;1.02) | 0.12 |
| Hap-E (CCTGAA) | 7.6 | 1.05 | (0.91;1.21) | 0.49 | 1.08 | (0.93;1.26) | 0.33 |
Abbreviations: FLAP, 5-lipoxygenase activating protein; LTA4-H, Leukotriene A4 hydroxylase.
The table displays hazard ratios from a weighted cox proportional hazards model. Haplotypes were defined as follows: Hap-A (rs17222814(G), rs4769874(G), rs9551963(A), rs10507391(T)), Hap-B (rs10507391(A), rs9315050(A), rs17222842(G)), Hap-K (rs61937881(C), rs2660880(G), rs6538697(T), rs1978331(T), rs17677715(T), rs2247570(A), rs2660898(T), rs2540482(G), rs2660845(G), rs2540475(C)), Hap-E (rs61937881(C), rs1978331(C), rs17677715(T), rs2660898(G), rs2540482(A), rs2660845(A)). Alleles correspond to the positive DNA-strand according to dbSNP, human assembly GRCh38.p2.
*Crude analyses. The pooled estimates are adjusted for sex.
**Adjusted analyses including sex(pooled analyses), smoking status, educational level, physical activity, BMI, waist circumference and alcohol consumption.
aUnadjusted p-value.