Table 1.
Characteristics of all patients.
| Characteristic | Drug | P value | ||
|---|---|---|---|---|
|
| ||||
| Cisplatin (n = 259) | 5FU/carboplatin (n = 52) | Cetuximab (n = 49) | ||
| n (%) | n (%) | n (%) | ||
| Age | <.0001 | |||
| <71 | 247 (95.4) | 41 (78.8) | 29 (59.2) | |
| ≥71 | 12 (4.6) | 11 (21.2) | 20 (40.8) | |
| Race | 0.33 | |||
| Caucasian | 234 (90.4) | 45 (86.5) | 41 (83.7) | |
| Non-Caucasian | 25 (9.7) | 7 (13.5) | 8 (16.3) | |
| Sex | 0.22 | |||
| Male | 225 (86.9) | 43 (82.7) | 38 (77.6) | |
| Female | 34 (13.1) | 9 (17.3) | 11 (22.4) | |
| Primary site | 0.22 | |||
| Oropharynx | 206 (79.5) | 38 (73.1) | 34 (69.4) | |
| Hypopharynx/larynx | 53 (20.5) | 14 (26.9) | 15 (30.6) | |
| T classification | 0.04 | |||
| T1 | 58 (22.4) | 9 (17.3) | 9 (18.4) | |
| T2 | 104 (40.2) | 12 (23.1) | 17 (34.7) | |
| T3 | 66 (25.5) | 17 (32.7) | 12 (24.5) | |
| T4 | 31 (12.0) | 14 (26.9) | 11 (22.4) | |
| N classification | 0.74 | |||
| N0 | 33 (12.7) | 3 (5.8) | 9 (12.2) | |
| N1 | 64 (24.7) | 14 (26.9) | 11 (22.5) | |
| N2 | 158 (61.0) | 34 (65.4) | 30 (61.2) | |
| N3 | 4 (1.5) | 1 (1.9) | 2 (4.1) | |
| Overall stage | 0.65 | |||
| II | 7 (2.7) | 0 (0) | 0 (0) | |
| III | 79 (30.5) | 13 (25.0) | 16 (32.7) | |
| IV | 173 (66.8) | 39 (75.0) | 33 (67.3) | |
| Alcohol history | 0.21 | |||
| Low/mild | 97 (37.5) | 17 (32.7) | 24 (49.0) | |
| Moderate/heavy | 162 (62.5) | 35 (67.3) | 25 (51.0) | |
| >10 pack-yr tobacco | 0.32 | |||
| No | 124 (47.9) | 19 (36.5) | 22 (44.9) | |
| Yes | 135 (52.1) | 33 (63.5) | 27 (55.1) | |
| KPS | ||||
| NA | 1 (0.4) | 1 (1.9) | 0 (0) | 0.02 |
| >80 | 201 (77.6) | 37 (71.2) | 29 (59.2) | |
| ≤80 | 57 (22.0) | 14 (26.9) | 20 (40.8) | |
| Cr clearancea | <.0001 | |||
| ≥60 | 245 (94.6) | 42 (80.8) | 35 (71.4) | |
| <60 | 14 (5.4) | 10 (19.2) | 14 (28.6) | |
| Charlson index | <.0001 | |||
| 0 | 187 (72.2) | 24 (46.2) | 29 (59.2) | |
| 1 | 49 (18.9) | 9 (17.3) | 13 (26.5) | |
| ≥2 | 23 (8.9) | 19 (36.5) | 7 (14.3) | |
| Pre-RT trach | ||||
| No | 250 (96.5) | 47 (90.4) | 45 (91.8) | |
| Yes | 9 (3.5) | 5 (9.6) | 4 (8.2) | |
| Neck dissection | .36 | |||
| No | 247 (95.4) | 51 (98.1) | 45 (91.8) | |
| Yes | 12 (4.6) | 1 (1.9) | 4 (8.2) | |
| Switched chemotherapy | .04 | |||
| No | 235 (90.7) | 46 (88.5) | 49 (100.0) | |
| Yes | 24 (9.3) | 6 (11.5) | 0 (0) | |
| Radiation length (days), median (range) | 46 (35–76) | 47 (42–58) | 46 (6–70) | .06 |
Abbreviations: RT = radiation therapy; KPS = Karnofsky performance status; Trach = tracheostomy; Cr = creatinine.
a
Calculated using Cockcroft-Gault formula.