Table 2.
Characteristics of 5FU/carboplatin versus cetuximab patients.
| Characteristic | Drug | P value | |
|---|---|---|---|
|
| |||
| 5FU/carboplatin (n = 52) | Cetuximab (n = 49) | ||
| n (%) | n (%) | ||
| Age | .03 | ||
| <71 | 41 (78.8) | 29 (59.2) | |
| ≥71 | 11 (21.2) | 20 (40.8) | |
| Race | .69 | ||
| Caucasian | 45 (86.5) | 41 (83.7) | |
| Non-Caucasian | 7 (13.5) | 8 (16.3) | |
| Sex | .52 | ||
| Male | 43 (82.7) | 38 (77.6) | |
| Female | 9 (17.3) | 11 (22.4) | |
| Primary site | .68 | ||
| Oropharynx | 38 (73.1) | 34 (69.4) | |
| Hypopharynx/larynx | 14 (26.9) | 15 (30.6) | |
| T classification | .57 | ||
| T1 | 9 (17.3) | 9 (18.4) | |
| T2 | 12 (23.1) | 17 (34.7) | |
| T3 | 17 (32.7) | 12 (24.5) | |
| T4 | 14 (26.9) | 11 (22.4) | |
| N classification | .61 | ||
| N0 | 3 (5.8) | 9 (12.2) | |
| N1 | 14 (26.9) | 11 (22.5) | |
| N2 | 34 (65.4) | 30 (61.2) | |
| N3 | 1 (1.9) | 2 (4.1) | |
| Overall stage | .40 | ||
| II | 0 (0) | 0 (0) | |
| III | 13 (25.0) | 16 (32.7) | |
| IV | 39 (75.0) | 33 (67.3) | |
| Alcohol history | .10 | ||
| Low/mild | 17 (32.7) | 24 (49.0) | |
| Moderate/heavy | 35 (67.3) | 25 (51.0) | |
| >10 pack-yr tobacco | .39 | ||
| No | 19 (36.5) | 22 (44.9) | |
| Yes | 33 (63.5) | 27 (55.1) | |
| KPS | .16 | ||
| NA | 1 (1.9) | 0 (0) | |
| >80 | 37 (71.2) | 29 (59.2) | |
| ≤80 | 14 (26.9) | 20 (40.8) | |
| Cr clearancea | .27 | ||
| ≥60 | 42 (80.8) | 35 (71.4) | |
| <60 | 10 (19.2) | 14 (28.6) | |
| Charlson index | .04 | ||
| 0 | 24 (46.2) | 29 (59.2) | |
| 1 | 9 (17.3) | 13 (26.5) | |
| ≥2 | 19 (36.5) | 7 (14.3) | |
| Pre-RT trach | 1.00 | ||
| No | 47 (90.4) | 45 (91.8) | |
| Yes | 5 (9.6) | 4 (8.2) | |
| Neck dissection | .20 | ||
| No | 51 (98.1) | 45 (91.8) | |
| Yes | 1 (1.9) | 4 (8.2) | |
| Switched chemotherapy | |||
| No | 46 (88.5) | 49 (100.0) | .03 |
| Yes | 6 (11.5) | 0 (0) | |
| Radiation length (days), median (range) | 47 (42–58) | 46 (6–70) | .34 |
Abbreviations: RT = radiation therapy; KPS = Karnofsky performance status; Trach = tracheostomy; Cr = creatinine.
a
Calculated using Cockcroft-Gault formula.