Table 1. Multicomponent assembly hemiaminal ether yield and dr formed with various pyridine carbaldehyde derivatives (2PA³, 2PA⁶, IQA, QA, 2PA, and PNA) and 1-phenylethanol ^a .

Code	Substituent	2PA3 assembly		2PA6 assembly
		Yield	dr	Yield	dr
2PA′F	F	87%	1.51	73%	1.45
2PA′Cl	Cl	87%	1.62	58%	1.71
2PA′Br	Br	86%	1.92	52%	1.61
2PA′MeO	MeO	96%	1.41	52%	1.89
2PA′Me	Me	97%	2.01	83%	2.28
2PA	H	83%	1.41	83%	1.41
IQA	3,4-Benzo	79%	1.45	n/a	n/a
QA	5,6-Benzo	<5%	n/a	n/a	n/a
PNA	Dibenzo	<5%	n/a	n/a	n/a

^aThe 3 and 6 subscribes designate the regiochemistry of PA substitution.