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. 2016 Jun 23;6(5):430–440. doi: 10.1016/j.apsb.2016.04.004

Figure 2.

Fig. 2

Observed (□) and PBPK model–simulated (-) plasma concentration–time profiles of YQA-14 in rats (A and B) and dogs (C and D) after a single i.v. (A and C) or (p.o.) (B and D) administration. Observed plasma concentration–time profiles (OBS) were obtained for rats and dogs after single i.v. and p.o. administration of YQA-14 at 25 and 5 mg/kg, respectively (n=3 rats/group; n=4 dogs/group). This figure is adapted from Ref. 12 with permission.