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. 2016 Jun 23;6(5):430–440. doi: 10.1016/j.apsb.2016.04.004

Figure 7.

Fig. 7

Application of physiologically based pharmacokinetic modeling and simulation in various stages of drug discovery and development. Models were initially built with preclinical data, and later refined with available clinical information. This figure was adapted from Ref. 15 with permission.