Skip to main content
. 2016 Jun 23;6(5):430–440. doi: 10.1016/j.apsb.2016.04.004

Table 6.

DDI analysis: simulated area under the concentration–time curve ratios for orteronel.

CYP/substrate Dose Orteronel IC50 (µmol/L)
CYP1A2/theophylline (SV) 125 mg TID 17.8
CYP2C8/repaglinide (SV) 0.25 mg BID 27.7
CYP2C9/(S)-warfarin (Sim) 10 mg QD 30.8
CYP2C19/omeprazole, enteric-coated (SV) 20 mg BID 38.8

Abbreviations: BID, twice daily; CYP, cytochrome P450; DDI, drug–drug interaction; IC50, 50% inhibitory concentration; QD, once daily; Sim, profile based on in vitro data; SV, profile based on in vivo data; TID, 3 times daily.

This table was adapted from Ref. 15 with permission.