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. 2016 Nov 22;11:6229–6238. doi: 10.2147/IJN.S112835

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© 2016 Yuan et al. This work is published and licensed by Dove Medical Press Limited

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(A) The kinetics of HCPT lactone to carboxylate conversion for free HCPT drug (■) and HCPT-sHDL (■). Solutions of HCPT and HCPT-sHDL were incubated in PBS pH 7.4 at 37°C and lactone-to-carboxylate ratio was determined by UPLC. (B) The kinetics of drug release HCPT-sHDL (○) compared with HCPT solution (■). Free HCPT and HCPT-sHDL were placed in dialysis bags and release was conducted in PBS pH 7.4 at 37°C.

Abbreviations: HCPT, 10-hydroxycamptothecin; sHDL, synthetic high-density lipoprotein; PBS, phosphate-buffered saline; UPLC, ultra performance liquid chromatography.