Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2016 Nov 18;11:6135–6148. doi: 10.2147/IJN.S117425

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2016 Li et al. This work is published and licensed by Dove Medical Press Limited

The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.

PMC Copyright notice

In vivo fluorescence imaging and effect of CNMs on VEGF and MMP-9 expression in rat cornea.

Notes: (A) Fluorescence micrographs of a cornea indicate the Mφ labeled with DiI located in cornea pockets on postoperative day 1 in the Mφ group and CNMs group. There were no DiI-labeled cells in the cornea pocket in the control group. Magnification ×25. (B) Confocal laser scanning microscopic images of a cornea indicate the protein expression of VEGF and MMP-9 on postoperative day 2. Visibly high expression of VEGF and MMP-9 was observed in implanted DiI-labeled Mφ, corneal stroma, and corneal endothelium in the Mφ group. There was a significant reduction in VEGF and MMP-9 expression in implanted Mφ and corneal stroma and endothelium in the CNMs group. No remarkable expression of VEGF and MMP-9 was observed in the control group.

Abbreviations: CNMs, celastrol nanomicelles; DiI, 1,19-dioctadecyl-3-3-39,39-tetramethylindocarbocyanine; Mφ, macrophage; MMP-9, matrix metalloproteinases 9; VEGF, vascular endothelial growth factor.