Table 2.
Effect of silica nanoparticles on the clinical chemistry parameters of liver and kidney function
| Control | Low | Med | High | |
|---|---|---|---|---|
| TP (g/L) | 71.67±4.02 | 73.37±5.98 | 72.62±1.46 | 74.05±4.69 |
| GLO (g/L) | 36.37±2.00 | 37.67±4.23 | 36.35±1.27 | 37.70±3.59 |
| ALB (g/L) | 35.30±2.07 | 35.70±1.88 | 36.27±0.81 | 36.35±1.68 |
| ALB/GLO | 0.97±0.02 | 0.98±0.02 | 1.00±0.04 | 0.97±0.08 |
| ALT (IU/L) | 20.25±3.71 | 19.75±0.85 | 17.63±1.14 | 20.55±3.49 |
| AST (IU/L) | 84.77±12.68 | 68.73±2.06 | 58.17±10.51b,* | 75.53±6.64b,* |
| LDH (U/L) | 568.37±91.54 | 533.65±145.58 | 509.32±180.39 | 301.40±41.17 |
| BUN (mmol/L) | 5.47±1.25 | 7.28±0.55a,* | 7.31±0.20a,* | 6.94±0.17c,* |
| Cr (mmol/L) | 12.07±1.77 | 7.47±0.85c,* | 10.87±1.56d,* | 8.85±3.70 |
| CA (μmol/L) | 92.75±10.11 | 86.25±4.11 | 80.00±3.61c,* | 115.00±18.52d,* |
Notes: Data are presented as mean ± SD, n=4. Low, 7 mg/kg dosage; med, 21 mg/kg dosage; high, 35 mg/kg dosage.
a
P<0.01, compared with the control group;
b
P<0.05, compared with the med group using one-way ANOVA;
c
P<0.05;
d
P<0.05, compared with the low group.
*
Significant differences.
Abbreviations: ANOVA, analysis of variance; TP, total protein; GLO, globulin; ALB, albumin; ALT, alanine aminotransferase; AST, aspartate aminotransferase; LDH, lactic dehydrogenase; BUN, blood urea nitrogen; Cr, creatinine; CA, uric acid.