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. 2016 Nov 18;11:6161–6168. doi: 10.2147/IJN.S113292

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© 2016 Fadhel et al. This work is published and licensed by Dove Medical Press Limited

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Demonstration of pH decrease and acid generation.

Notes: (A) Acidic content increasing in the lysosomes as a function of exposure time in HCT-116 cells incubated with PEG–PAG9 (50 μM) for 24 h and with 1 μM of LysoSensor Green for 2 h after 5 s irradiation, 5.4 mW/cm² (blue dots). Black dots represent cells incubated only with LysoSensor Green. (B) Increase in fluorescence intensity of LysoSensor Green in the presence of PEG–PAG9 at different irradiation times.

Abbreviations: PEG, polyethylene glycol; PAG, photoacid generator.