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. 2016 Nov 23;11:6251–6265. doi: 10.2147/IJN.S118196

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© 2016 Alvarez-Berríos and Vivero-Escoto. This work is published and licensed by Dove Medical Press Limited

The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.

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Schematic representation of the FA-conjugated cisplatin(IV) prodrug MSN platform developed in this work.

Notes: The MSN-delivery system contains cisplatin(IV) prodrug chemically attached to the surface of the nanoparticle and is decorated with FA-PEG-NH₂ that targets FA receptors overexpressed in HeLa cancer cells. The FA-conjugated-cisplatin(IV) prodrug MSNs are internalized through a receptor-mediated endocytosis mechanism, escape from lysosomes, and release the cisplatin, due to the highly reducing environment found in the cytosol of cancer cells. The released cisplatin travels to the cell nucleus to form DNA adducts, which triggers apoptosis.

Abbreviations: FA, folic acid; MSN, mesoporous silica nanoparticle; PEG, polyethylene glycol.