Table 3.
IOP (mmHg) changes in patients stratified by risk factors: age, diabetes, and glaucoma
| Categories | Baselineb | TP1b | Δ from baselinea | TP2b | Δ from baselinea | ≥21 mmHg, overall and ≥10 mmHg, increase at TP1c |
|---|---|---|---|---|---|---|
| >75 years old (n=1,001) | 14.7 (3.2) | 15.9 (4.5)** | 1.2 (4.7)** | 14.5 (3.4)* | −0.20 (4.0)* | 30 (3.0) |
| ≤75 years old (n=2,487) | 14.6 (3.2) | 15.4 (4.0)** | 0.85 (4.5)** | 14.1 (2.9)** | −0.52 (3.6)** | 94 (3.8) |
| Δ mean IOP (95% CI) | −0.09 (−0.32, 0.15) | 0.48 (−0.80, −0.16) | −0.45 (−0.75, −0.14) | −0.41 (−0.65, −0.16) | −0.38 (−0.62, −0.15) | N/A |
| P-value | 0.47 | 0.003 | 0.004 | 0.001 | 0.001 | 0.25 |
| >75 years of age | ||||||
| Prednisolone (n=617) | 14.7 (3.1) | 15.4 (4.1)** | 0.68 (4.5)** | 14.1 (3.0)** | −0.57 (3.5)** | 19 (3.1) |
| Difluprednate (n=384) | 14.5 (3.3) | 15.6 (3.8)** | 1.1 (4.4)** | 14.0 (2.8)* | −0.44 (3.7)* | 11 (2.9) |
| Δ mean IOP | −0.19 (−0.60, 0.21) | 0.22 (−0.29, 0.73) | 0.09 (−0.08, 0.26) | −0.05 (−0.42, 0.32) | 0.001 (−0.12, 0.12) | N/A |
| P-value | 0.36 | 0.40 | 0.28 | 0.78 | 0.991 | 0.84 |
| Diabetes (n=641) | 15.0 (3.2) | 15.9 (4.3)** | 1.2 (4.6)** | 14.4 (3.1)** | −0.22 (3.9)** | 100 (3.5) |
| Non-diabetes (n=2,847) | 14.6 (3.2) | 15.8 (4.4)** | 0.91 (4.7)** | 14.4 (3.4)* | −0.62 (3.9)* | 24 (3.7) |
| Δ mean IOP (95% CI) | 0.47 (0.19, 0.74) | 0.20 (−0.16, 0.58) | 0.03 (−0.33, 0.39) | 0.07 (−0.21, 0.35) | −0.06 (−0.33, 0.21) | N/A |
| P-value | <0.001 | 0.28 | 0.87 | 0.60 | 0.67 | 0.78 |
| Diabetes patients | ||||||
| Prednisolone (n=388) | 15.1 (3.3) | 15.9 (4.6)* | 0.76 (4.9)* | 14.4 (3.2)** | −0.74 (4.03)** | 15 (3.9) |
| Difluprednate (n=356) | 14.9 (3.1) | 16.1 (3.9)** | 1.1 (4.3)** | 14.6 (3.1) | −0.42 (3.9) | 9 (3.6) |
| Δ mean IOP | −0.13 (−0.64, 0.39) | 0.25 (−0.43, 0.93) | 0.10 (−0.12, 0.32) | 0.20 (0.29, 0.70) | 0.08 (−0.09, 0.23) | N/A |
| P-value | 0.63 | 0.47 | 0.87 | 0.43 | 0.36 | 0.84 |
| Glaucoma (n=548) | 15.6 (3.6) | 17.5 (5.4)** | 1.9 (5.6)** | 15.2 (3.8)* | −0.40 (4.4)* | 41 (7.5) |
| Non-glaucoma (n=2,940) | 14.5 (3.1) | 15.5 (4.1)** | 1.0 (4.4)** | 14.2 (3.2)** | −0.27 (3.8)** | 83 (2.8) |
| Δ mean IOP (95% CI) | 1.1 (0.81, 1.4) | 2.0 (1.6, 2.4) | 1.6 (1.2, 2.0) | 0.97 (0.67, 1.3) | 0.67 (0.38, 0.96) | N/A |
| P-value | <0.001 | <0.001 | <0.001 | <0.001 | <0.001 | <0.001 |
| Glaucoma patients | ||||||
| Prednisolone (n=353) | 15.8 (3.6) | 17.4 (5.2)** | 1.6 (5.4)** | 15.2 (3.8)* | −0.54 (4.1)* | 23 (5.6) |
| Difluprednate (n=195) | 15.3 (3.7) | 17.6 (5.7)** | 2.4 (5.9)** | 15.1 (3.9) | −0.15 (4.3) | 18 (9.2) |
| Δ mean IOP | −0.52 (−1.1, 0.12) | 0.23 (−0.71, 1.2) | 0.15 (−0.15, 0.46) | −0.13 (−0.80, 0.54) | 0.02 (−0.18, 0.23) | N/A |
| P-value | 0.11 | 0.62 | 0.33 | 0.70 | 0.82 | 0.25 |
Notes: Data shown as mean (SD), mean change (SD), n (%), Δ mean (95% CI), or P-value.
a
P-values calculated using the analysis of covariance adjusted for baseline IOP.
b
P-values calculated using the Independent t-test.
c
P-values calculated using Fisher’s exact test.
*
Denotes P-value <0.05 comparing mean IOP change at each time point from baseline after multiple comparison adjustments.
**
Denotes P-value <0.001 comparing mean IOP change at each time point from baseline after multiple comparison adjustments.
Abbreviations: IOP, intraocular pressure; TP1, 5–10 days postoperatively; TP2, 3–6 weeks postoperatively.