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. 2016 Nov 24;10:3867–3872. doi: 10.2147/DDDT.S119162

Table 1.

Formula, systematic name and structure of small-molecule EGFR TKIs

Generic name Trade name Formula Systematic name Structure
Erlotinib Tarceva® C22H23N3O4 N-(3-ethynylphenyl)-6,7-bis(2-methoxyethoxy)quinazolin-4-amine graphic file with name dddt-10-3867Fig1.jpg
Gefitinib Iressa® C22H24ClFN4O3 N-(3-chloro-4-fluoro-phenyl)-7-methoxy-6-(3-morpholin-4-ylpropoxy)quinazolin-4-amine graphic file with name dddt-10-3867Fig2.jpg
Afatinib Gilotrif® C24H25ClFN5O3 N-[4-[(3-chloro-4-fluorophenyl)amino]-7-[[(3S)-tetrahydro-3-furanyl]oxy]-6-quinazolinyl]-4(dimethylamino)-2-butenamide graphic file with name dddt-10-3867Fig3.jpg
Dacomitinib C24H25ClFN5O2 (2E)-N-{4-[(3-chloro-4-fluorophenyl)amino]-7-methoxy-6-quinazolinyl}-4-(1-piperidinyl)-2-butenamide graphic file with name dddt-10-3867Fig4.jpg
Neratinib C30H29ClN6O3 (2E)-N-[4-[[3-chloro-4-[(pyridin-2-yl)methoxy]phenyl]amino]-3-cyano-7-ethoxyquinolin-6-yl]-4-(dimethylamino)but-2-enamide graphic file with name dddt-10-3867Fig5.jpg
Osimertinib Tagrisso™ C28H33N7O2·CH4O3S N-(2-{2-dimethylaminoethyl-methylamino}-4-methoxy-5-{[4-(1-methylindol-3-yl)pyrimidin-2yl]amino}phenyl)prop-2-enamide mesylate salt graphic file with name dddt-10-3867Fig6.jpg
Olmutinib C26H26N6O2S N-[3-({2-[4-(4-methylpiperazin-1-yl)anilino]thieno[3,2-d]pyrimidin-4-yl}oxy)phenyl]prop-2-enamide graphic file with name dddt-10-3867Fig7.jpg
Rociletinib C27H28F3N7O3 N-[3-[[2-[4-(4-acetylpiperazin-1-yl)-2-methoxyanilino]-5-(trifluoromethyl)pyrimidin-4-yl]amino]phenyl]prop-2-enamide graphic file with name dddt-10-3867Fig8.jpg

Abbreviations: EGFR, epidermal growth factor receptor; TKI, tyrosine kinase inhibitor.